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    產品資料

    Rat CD6 / TP120 Protein|報價| 產品詳情

    產品名稱: Rat CD6 / TP120 Protein|報價| 產品詳情
    產品型號: C86-803-11
    產品展商: 博飛美科
    產品文檔: 無相關文檔

    簡單介紹

    Rat CD6 / TP120 Protein|報價| 產品詳情由上海創賽科學儀器有限公司品質提供,可查詢Rat CD6 / TP120 Protein價格。上海創賽科學儀器有限公司是專業**試劑生產及供應商,其優良的品質滿足您不同實驗的多種需求,歡迎撥打4006087598洽談選購,更多產品詳情請登錄www.getprovidencehotels.com


    Rat CD6 / TP120 Protein|報價| 產品詳情  的詳細介紹

    CD6 / TP120蛋白產品信息

    別名: CD6
    表達方式: 
    A DNA sequence encoding the rat CD6 (Q812A4) (Met1-Asn396) was expressed with a polyhistidine tag at the C-terminus.
    種屬: Rat
    表達宿主: Human Cells

    CD6 / TP120 Protein QC Testing

    純度: > 95 % as determined by SDS-PAGE SDS-PAGE
    內**: < 1.0 EU per μg of the protein as determined by the LAL method
    穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
    預測N端: Leu 18
    分子量: 
    The recombinant rat CD6 comprises 390 amino acids and predicts a molecular mass of 42.5 kDa. The apparent molecular mass of  the recombinant protein is approximately 64-70 kDa in SDS-PAGE under reducing conditions due to glycosylation.
    緩沖液: Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
    Please contact us for any concerns or special requirements.

    CD6 / TP120 Protein Usage Guide

    儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
    Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

    CD6 / TP120蛋白背景綜述

    T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

    參考文獻

    Joo YS. et al., 2000, Arthritis Rheum. 43 (2): 329-35.
    Singer NG. et al., 2002, Int Immunol. 14 (6): 585-97.
    Gimferrer I. et al., 2005, J Immunol. 175 (3): 1406-14.
    Alonso R. et al., 2010, J Autoimmun. 35 (4): 336-41.

    規格:100ug

    關 鍵 詞:Rat CD6 / TP120 Protein,報價, 產品詳情,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家

    CANSPEC品質提供的Rat CD6 / TP120 Protein|報價| 產品詳情性能**,其優良的品質滿足您不同實驗的多種需求。

    本產品由上海創賽品質提供,歡迎咨詢國內免費服務專線:400-608-7598,更多產品信息請登錄www.getprovidencehotels.com 或 www.4006087598.com

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