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    產品資料

    Rat CSF1R / M-CSFR Protein|技術資料|價格

    產品名稱: Rat CSF1R / M-CSFR Protein|技術資料|價格
    產品型號: C86-804-47
    產品展商: 博飛美科
    產品文檔: 無相關文檔

    簡單介紹

    Rat CSF1R / M-CSFR Protein|技術資料|價格由上海創賽科學儀器有限公司品質提供,可查詢Rat CSF1R / M-CSFR Protein價格。上海創賽科學儀器有限公司是專業**試劑生產及供應商,其優良的品質滿足您不同實驗的多種需求,歡迎撥打4006087598洽談選購,更多產品詳情請登錄www.getprovidencehotels.com


    Rat CSF1R / M-CSFR Protein|技術資料|價格  的詳細介紹

    CSF1R / M-CSFR蛋白產品信息

    別名: CSF1R
    表達方式: 
    A DNA sequence encoding the rat CSF1R (D4ACA7) (Met1-Glu510) was expressed with a polyhistidine tag at the C-terminus.
    種屬: Rat
    表達宿主: Human Cells

    CSF1R / M-CSFR Protein QC Testing

    純度: > 95 % as determined by SDS-PAGE SDS-PAGE
    內**: < 1.0 EU per μg of the protein as determined by the LAL method
    穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
    預測N端: Ala 20
    分子量: 
    The recombinant rat CSF1R comprises 502 amino acids and predicts a molecular mass of 56.5 kDa. The apparent molecular mass of  the recombinant protein is approximately 69-89 kDa in SDS-PAGE under reducing conditions due to glycosylation.
    緩沖液: Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
    Please contact us for any concerns or special requirements.

    CSF1R / M-CSFR Protein Usage Guide

    儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
    Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

    CSF1R / M-CSFR蛋白背景綜述

    M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1, a cytokine involved in the proliferation, differentiation, and activation of macrophages. As a member of the typeIII subfamily of receptor tyrosine kinases (RTKs), M-CSF receptor is expressed mainly on cells of monocyte/macrophage lineage, and consists of an extracellular ligand-binding domain and a cytoplasmic protein tyrosine kinase (PTK) domain joined through a single transmembrane helix. Ligand binding induces the M-CSF receptor homodimerization, and leads to transphosphorylation of specific tyrosine and the subsequent signal transduction. This activated receptor exerts actions on multiple intracellular effectors which determine the magnitude and specificity of the biological responses, and thus mediates most if not all of the biological effects of the CSF1 cytokine, including cell growth, survival, differentiation and chemotaxis. Mutations of this gene have been associated with a predisposition to myeloid malignancy.

    參考文獻

    Sherr CJ. 1988, Biochim Biophys Acta. 948: 225-43.
    Rohrschneider LR. et al., 1997, Mol Reprod Dev. 46: 96-103.
    Hamilton JA. et al., 1997, J Luekoc Biol. 62: 145-55.
    Roussel MF. et al., 1991, Nature. 353: 361-3.
    Yeung Y. et al., 1998, J Biol Chem. 273.
    Pixley FJ. et al., 2004, Trends Cell Biol. 14: 628-38.
    Rovida E. et al., 2001, J Immunol. 166: 1583-9.

    規格:50ug

    關 鍵 詞:Rat CSF1R / M-CSFR Protein,技術資料,價格,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家

    CANSPEC品質提供的Rat CSF1R / M-CSFR Protein|技術資料|價格性能**,其優良的品質滿足您不同實驗的多種需求。

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