ICAM4 / CD242蛋白產品信息
別名: ICAM4, LW 表達方式: A DNA sequence encoding the human ICAM4 (NP_001034221.1) (Met1-Gly272) was expressed with the Fc region of human IgG1 at the C-terminus. 種屬: Human 表達宿主: Human Cells ICAM4 / CD242 Protein QC Testing
純度: (50.3+36.1) % as determined by SDS-PAGE SDS-PAGE 內**: < 1.0 EU per μg of the protein as determined by the LAL method 穩定性: Samples are stable for up to twelve months from date of receipt at -70℃ 預測N端: Ala 23 分子量: The recombinant human ICAM4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 491 amino acids and has a predicted molecular mass of 54.4 kDa. The apparent molecular mass of the protein is approximately 55 and 33 kDa in SDS-PAGE under reducing conditions. 緩沖液: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. ICAM4 / CD242 Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. ICAM4 / CD242蛋白背景綜述
ICAM4, also known as CD242, is a member of the?immunoglobulin superfamily, ICAM family. ICAM4 contains 2?Ig-like C2-type (immunoglobulin-like) domains. It is similar to the intercellular adhesion molecule (ICAM) protein family. ICAM4 binds to the leukocyte adhesion LFA-1 protein. ICAM4's first reported receptors were CD11a/CD18 and CD11b/CD18. ICAM4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM4 demonstrated that both its domains contain binding sites for CD11c/CD18. CD11c/CD18 is expressed on macrophages in spleen and bone marrow. Inhibition of erythrophagocytosis by anti-ICAM4 and anti-integrin antibodies suggests a role for these interactions in removal of senescent red cells. 參考文獻
Gorst DW. et al., 1980, Vox Sanguinis. 38 (2): 99-105. Vos GH. et al., 1973, Blood. 42 (3): 445-53. Kim W. et al., 2011, Mol Cell. 44 (2): 325-40. Daniels G. et al., 2002, Transfusion Medicine. 12 (5): 287-95. 規格:50ug 關 鍵 詞:ICAM4 / CD242 Protein,廠家現貨,報價,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家
CANSPEC品質提供的ICAM4 / CD242 Protein|廠家現貨|報價性能**,其優良的品質滿足您不同實驗的多種需求。
本產品由上海創賽品質提供,歡迎咨詢國內免費服務專線:400-608-7598,更多產品信息請登錄www.getprovidencehotels.com 或 www.4006087598.com
國內免費服務專線:400 608 7598(據說天才可以在15秒內記住我們的免費電話哦^_^)
服務升級,全新企業QQ為您服務,企業QQ號:4006087598
創賽官網升級為創賽優選商城,請移步www.canspec.cn注冊登錄,新用戶注冊送1000元現金券
滬公網安備 31011402005168號