CD300A蛋白產品信息
別名: CD300A, CMRF35H, IGSF12
表達方式:
A DNA sequence encoding the human CD300A (Q9UGN4-1)(Met1-Gln178) was expressed with the Fc region of human IgG1 at the C-terminus.
種屬: Human
表達宿主: Human Cells
CD300A Protein QC Testing
純度: (97.9+1.1)% as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Leu 18
分子量:
The recombinant human CD300A/Fc is a disulfide-linked homodimer. The reduced monomer comprises 402 amino acids and has a predicted molecular mass of 44.5 kDa. The apparent molecular mass of the protein is approximately 58-66 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
CD300A Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD300A蛋白背景綜述
CMRF35-like molecule 8, also known as CD300 antigen-like family member A, CMRF35-H9, Immunoglobulin superfamily member 12, Inhibitory receptor protein 60, NK inhibitory receptor, CD300a and CMRF35H, is a single-pass type I membrane protein which belongs to the CD300 family. The CD300 family of myeloid immunoglobulin receptors includes activating (CD300b, CD300e) and inhibitory members (CD300a, CD300f), as well as molecules presenting a negative charge within their transmembrane domain (CD300c, CD300d). CD300A / IGSF12 is expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.It contains one Ig-like V-type (immunoglobulin-like) domain. CD300A / IGSF12 is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells. CD300c signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FcεRγ. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from plasmacytoid dendritic cells (pDCs).
參考文獻
Bachelet I. et al., 2005, J. Immunol. 175: 7989-95.
Bachelet I. et al., 2008, J Immunol. 180 (9): 6064-9.
Ju X. et al., 2008, Blood. 112 (4): 1184-94.
Martínez-Barriocanal A. et al., 2010, J Biol Chem. 285 (53): 41781-94.
Lankry D. et al., 2010, J Immunol. 185 (5): 2877-86.
規格：50ug
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