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    產品資料

    Canine 4-1BB / TNFRSF9 Protein|使用說明書|廠家現貨

    產品名稱: Canine 4-1BB / TNFRSF9 Protein|使用說明書|廠家現貨
    產品型號: C86-700-95
    產品展商: 博飛美科
    產品文檔: 無相關文檔

    簡單介紹

    Canine 4-1BB / TNFRSF9 Protein|使用說明書|廠家現貨由上海創賽科學儀器有限公司品質提供,可查詢Canine 4-1BB / TNFRSF9 Protein價格。上海創賽科學儀器有限公司是專業**試劑生產及供應商,其優良的品質滿足您不同實驗的多種需求,歡迎撥打4006087598洽談選購,更多產品詳情請登錄www.getprovidencehotels.com


    Canine 4-1BB / TNFRSF9 Protein|使用說明書|廠家現貨  的詳細介紹

    4-1BB / TNFRSF9蛋白產品信息

    別名: TNFRSF9
    表達方式: 
    A DNA sequence encoding the canine TNFRSF9 (XP_850336.1) (Met1-Ser185) was expressed with a C-terminal polyhistidine tag.
    種屬: Canine
    表達宿主: Human Cells

    4-1BB / TNFRSF9 Protein QC Testing

    純度: > 95 % as determined by SDS-PAGE SDS-PAGE
    內**: < 1.0 EU per μg of the protein as determined by the LAL method
    穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
    預測N端: Ile 24
    分子量: 
    The recombinant canine TNFRSF9 comprises 173 amino acids and has a predicted molecular mass of 18.4 kDa. The apparent molecular mass of the protein is approximately 28-34 kDa in SDS-PAGE under reducing conditions due to glycosylation.
    緩沖液: Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
    Please contact us for any concerns or special requirements.

    4-1BB / TNFRSF9 Protein Usage Guide

    儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
    Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

    4-1BB / TNFRSF9蛋白背景綜述

    Tumor necrosis factor receptor superfamily member 9, also known as 4-1BB ligand receptor, CD137, TNFRSF9 and ILA, is a single-pass type I membrane protein which is expressed on the surface of activated T-cells. 4-1BB / CD137 is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer.

    參考文獻

    Alderson MR. et al., 1994, Eur J Immunol. 24:2219-27.
    Ma BY. et al., 2005, Blood. 106: 2002-10.
    Wen T. et al., 2002, J Immunol. 168: 4897-906.
    Melero I. et al., 1997, Nat Med. 3: 682-5.
    Saito K. et al., 2004, J. Biol. Chem. 14: 13555-63.
    Kienzle G. et al., 2000, Int Immunol. 12: 73-82.
    Li Q. et al., 2003, Immunology. 63: 2546-52.

    規格:100ug

    關 鍵 詞:Canine 4-1BB / TNFRSF9 Protein,使用說明書,廠家現貨,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家

    CANSPEC品質提供的Canine 4-1BB / TNFRSF9 Protein|使用說明書|廠家現貨性能**,其優良的品質滿足您不同實驗的多種需求。

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