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    產品資料

    GPHA2 / Glycoprotein hormone alpha 2 Protein|廠家現貨|產品詳情

    產品名稱: GPHA2 / Glycoprotein hormone alpha 2 Protein|廠家現貨|產品詳情
    產品型號: C86-138-94
    產品展商: 博飛美科
    產品文檔: 無相關文檔

    簡單介紹

    GPHA2 / Glycoprotein hormone alpha 2 Protein|廠家現貨|產品詳情由上海創賽科學儀器有限公司品質提供。上海創賽科學儀器有限公司是專業**試劑生產及供應商,其優良的品質滿足您不同實驗的多種需求,歡迎撥打4006087598洽談選購,更多產品詳情請登錄www.getprovidencehotels.com


    GPHA2 / Glycoprotein hormone alpha 2 Protein|廠家現貨|產品詳情  的詳細介紹

    GPHA2 / Glycoprotein hormone alpha 2蛋白產品信息

    別名: GPHA2, GPA2, ZSIG51
    表達方式: 
    A DNA sequence encoding the human GPHA2 (Q96T91) (Met 1- Tyr129) was expressed with a polyhistidine tag at the C-terminus.
    種屬: Human
    表達宿主: Human Cells

    GPHA2 / Glycoprotein hormone alpha 2 Protein QC Testing

    純度: > 90 % as determined by SDS-PAGE SDS-PAGE
    內**: < 1.0 EU per μg of the protein as determined by the LAL method
    穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
    預測N端: Gln 24
    分子量: 
    The recombinant human GPHA2 consists of  117 amino acids and predicts a molecular mass of  13.1 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.
    緩沖液: Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
    Please contact us for any concerns or special requirements.

    GPHA2 / Glycoprotein hormone alpha 2 Protein Usage Guide

    儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
    Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

    GPHA2 / Glycoprotein hormone alpha 2蛋白背景綜述

    GPHA2 is a member of the glycoprotein hormones subunit alpha family. Glycoprotein hormones consist of two subunits, the common alpha- and specific beta-subunits, which associate noncovalently to form a heterodimer. The alpha-subunit combines with four distinct beta-subunits giving rise to four biologically active hormones in human: FSH, LH, TSH, and CG. GPHA2 and glycoprotein hormone beta 5 (GPHB5) can form a noncovalent heterodimer. GPHA2 can be detected in a variety of tissues. Recombinant A2/B5 heterodimeric glycoproteins activates human TSH receptors, but not LH and FSH receptors, and shows high affinity to TSH receptors in a radioligand receptor assay. The heterodimer also stimulates cAMP production and thymidine incorporation by cultured thyroid cells and increases serum thyroxine levels in TSH-suppressed rats in vivo. This new heterodimeric glycoprotein hormone was named as thyrostimulin based on its thyroid-stimulating activity. The expression of thyrostimulin in the anterior pituitary known to express TSH receptors suggested a paracrine mechanism.

    參考文獻

    Hsu SY. et al., 2002, Science. 295 (5555): 671-4.
    Suzuki C. et al., 2007, Regul Pept. 142 (1-2): 60-7.
    Breous E. et al., 2006, Mol Cell Endocrinol. 245 (1-2): 169-80.

    規格:20ug

    關 鍵 詞:GPHA2 / Glycoprotein hormone alpha 2 Protein,廠家現貨,產品詳情,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家

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    本產品由上海創賽品質提供,歡迎咨詢國內免費服務專線:400-608-7598,更多產品信息請登錄www.getprovidencehotels.com 或 www.4006087598.com

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