CD33 / Siglec-3 Protein|CD33 / Siglec-3蛋白質|廠家現貨|參數

CD33 / Siglec-3蛋白產品信息

別名: CD33, SIGLEC3
表達方式: 
A DNA sequence encoding the human CD33 (AAH28152.1) (Met1-His259) was expressed with a C-terminal polyhistidine tag.
種屬: Human
表達宿主: Human Cells

CD33 / Siglec-3 Protein QC Testing

純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Asp 18
分子量: 
The recombinant human CD33  comprises 253 amino acids and has a predicted molecular mass of 28.2 kDa. The apparent molecular mass of the protein is approximately 40-46 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4, 10% glycerol.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD33 / Siglec-3 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD33 / Siglec-3蛋白背景綜述

Myeloid cell surface antigen CD33, also known as Sialic acid-binding Ig-like lectin 3, SIGLEC3 and CD33, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD33 / Siglec-3 contains 1 Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. CD33 / Siglec-3 is an adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 / Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia. CD33 / Siglec-3 is becoming increasingly important as a target of antibody-mediated therapy in acute myeloid leukaemia (AML).

參考文獻

Bernstein ID. et al., 2002, Clin Lymphoma. 1: S9-11.
Hauswirth AW. et al., 2007, Eur J Clin Invest. 37 (1): 73-82.
Shamsasenjan K. et al., 2009, Int J Hematol. 89 (3): 310-8.
Abdool A. et al., 2010, Exp Hematol. 38 (6): 462-71.

規格：50ug

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