Cynomolgus CDCP1 Protein|廠家現貨|價格

CDCP1蛋白產品信息

別名: CDCP1
表達方式: 
A DNA sequence encoding the cynomolgus CDCP1 (XP_001114659.1) (Met1-Thr667)  was expressed with a polyhistidine tag at the C-terminus.
種屬: Cynomolgus
表達宿主: Human Cells

CDCP1 Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Phe 30
分子量: 
The recombinant cynomolgus CDCP1 comprises 649 amino acids and has a calculated molecular mass of 73.4 KDa. The apparent molecular mass of it is approximately 93-113 KDa  in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CDCP1 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CDCP1蛋白背景綜述

CDCP1 is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. CDCP1 is a key regulator of EGF/EGFR-induced cell migration. It may be a rational approach to inhibit progression of cancers driven by EGFR signaling including those resistant to anti-EGFR drugs because of activating mutations in the RAS/RAF/MEK/ERK pathway. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.

參考文獻

Conze T. et al., 2003, Ann N Y Acad Sci. 996 (1): 222-6.
Hooper JD. et al., 2003, Oncogene. 22 (12): 1783-94.
Scherl-Mostageer M. et al., 2001, Oncogene. 20 (32): 4402-8.

規格：20ug

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