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    產品資料

    IL12A & IL27B Heterodimer Protein|廠家現貨|技術資料

    產品名稱: IL12A & IL27B Heterodimer Protein|廠家現貨|技術資料
    產品型號: C86-CT0-40
    產品展商: 博飛美科
    產品文檔: 無相關文檔

    簡單介紹

    IL12A & IL27B Heterodimer Protein|廠家現貨|技術資料由上海創賽科學儀器有限公司品質提供,可查詢IL12A & IL27B Heterodimer Protein價格。上海創賽科學儀器有限公司是專業**試劑生產及供應商,其優良的品質滿足您不同實驗的多種需求,歡迎撥打4006087598洽談選購,更多產品詳情請登錄www.getprovidencehotels.com


    IL12A & IL27B Heterodimer Protein|廠家現貨|技術資料  的詳細介紹

    IL12A & IL27B Heterodimer蛋白產品信息

    別名: IL12A & IL27B
    表達方式: 
    A DNA sequence encoding the p35 subunit of human IL12, termed as IL12A (NP_000873.2) (Met1-Ser219) was fused with the C-terminal His-tagged Fc region of human IgG1 at the C-terminus, constructed the plasmid 1; A DNA sequence encoding the human IL27B, (NP_005746.2) (Met1-Lys229) was fused with the C-terminal flag-tagged Fc region of human IgG1 at the C-terminus, constructed the plasmid 2. The two plasmids were co-expressed and the heterodimer was purified.
    種屬: Human
    表達宿主: Human Cells

    IL12A & IL27B Heterodimer Protein QC Testing

    純度: (59.8+33.3) % as determined by SDS-PAGE SDS-PAGE
    內**: < 1.0 EU per μg of the protein as determined by the LAL method
    穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
    預測N端: Arg 23 & Arg 21
    分子量: 
    The recombinant human IL12A&IL27B comprises 905 (447+458) amino acids and has a calculated molecular mass of 102 (50.7+ 51.3) KDa. The apparent molecular mass of the recombinant human IL12A&IL27B is approximately 60 & 63 KDa respectively in SDS-PAGE under reducing conditions.
    緩沖液: Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
    Please contact us for any concerns or special requirements.

    IL12A & IL27B Heterodimer Protein Usage Guide

    儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
    Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

    IL12A & IL27B Heterodimer蛋白背景綜述

    IL12A is a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL12A, together with IL27B, form a disulfide-linked heterodimer: IL12A&IL27B. IL12A&IL27B is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of IL12A&IL27B in innate immunity.

    參考文獻

    Muthumani K. et al., 2004, DNA Cell Biol. 23 (4): 239-47.
    Airoldi I. et al., 2002, Haematologica. 87 (4): 434-42.
    Wolf SF. et al., 1991, J Immunol. 146 (9): 3074-81.

    規格:10ug

    關 鍵 詞:IL12A & IL27B Heterodimer Protein,廠家現貨,技術資料,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家

    CANSPEC品質提供的IL12A & IL27B Heterodimer Protein|廠家現貨|技術資料性能**,其優良的品質滿足您不同實驗的多種需求。

    本產品由上海創賽品質提供,歡迎咨詢國內免費服務專線:400-608-7598,更多產品信息請登錄www.getprovidencehotels.com 或 www.4006087598.com

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