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    產品資料

    CD47 Protein|CD47蛋白|使用說明|價格

    產品名稱: CD47 Protein|CD47蛋白|使用說明|價格
    產品型號: C86-122-83
    產品展商: 博飛美科
    產品文檔: 無相關文檔

    簡單介紹

    CD47 Protein|CD47蛋白|使用說明|價格由上海創賽科學儀器有限公司品質提供,可查詢CD47 Protein價格。上海創賽科學儀器有限公司是專業**試劑生產及供應商,其優良的品質滿足您不同實驗的多種需求,歡迎撥打4006087598洽談選購,更多產品詳情請登錄www.getprovidencehotels.com


    CD47 Protein|CD47蛋白|使用說明|價格  的詳細介紹

    CD47蛋白產品信息

    別名: CD47, MER6
    表達方式: 
    A DNA sequence encoding the human CD47 (NP_942088.1) (Met1-Pro139) was expressed with the Fc region of human IgG1 at the C-terminus.
    種屬: Human
    表達宿主: Human Cells

    CD47 Protein QC Testing

    純度: > 95 % as determined by SDS-PAGE SDS-PAGE
    內**: < 1.0 EU per μg of the protein as determined by the LAL method
    穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
    預測N端: Gln 19
    分子量: 
    The recombinant human CD47/Fc is a disulfide-linked homodimer. The reduced monomer comprises 362 amino acids and has a predicted molecular mass of 40.7 kDa. The apparent molecular mass of the protein is approximately 48-60 kDa in SDS-PAGE under reducing conditions.
    緩沖液: Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
    Please contact us for any concerns or special requirements.

    CD47 Protein Usage Guide

    儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
    Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

    CD47蛋白背景綜述

    CD47 is a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. CD47 gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and interacts with THBS1 and fibrinogen. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Its interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

    參考文獻

    Brown EJ. et al., 2001, Trends Cell Biol. 11 (3): 130-5.
    Oldenborg PA. 2004, Leuk Lymphoma. 45 (7): 1319-27.
    Kaczorowski DJ. et al., 2007, Circ Res. 100 (5): 602-3.

    規格:50ug

    關 鍵 詞:CD47 Protein,CD47蛋白,使用說明,價格,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家

    CANSPEC品質提供的CD47 Protein|CD47蛋白|使用說明|價格性能**,其優良的品質滿足您不同實驗的多種需求。

    本產品由上海創賽品質提供,歡迎咨詢國內免費服務專線:400-608-7598,更多產品信息請登錄www.getprovidencehotels.com 或 www.4006087598.com

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