CES3 / Carboxylesterase-3蛋白產品信息
別名: CES3, Ces1d, Ces1 表達方式: A DNA sequence encoding the mouse CES3 (NP_444430.2) (Met1-Glu561) was expressed with a C-terminal polyhistidine tag. 種屬: Mouse 表達宿主: Human Cells CES3 / Carboxylesterase-3 Protein QC Testing
純度: > 90 % as determined by SDS-PAGE SDS-PAGE 內**: < 1.0 EU per μg of the protein as determined by the LAL method 穩定性: Samples are stable for up to twelve months from date of receipt at -70℃ 預測N端: Tyr 19 分子量: The recombinant mouse CES3 comprises 554 amino acids and has a predicted molecular mass of 60.8 kDa. The apparent molecular mass of the protein is approximately 53 kDa in SDS-PAGE under reducing conditions. 緩沖液: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. CES3 / Carboxylesterase-3 Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. CES3 / Carboxylesterase-3蛋白背景綜述
Carboxylesterases hydrolyze esters of short-chain fatty acids and have roles in animals ranging from signal transduction to xenobiotic detoxification. In enzymology, a carboxylesterase is an enzyme that catalyzes the chemical reaction: a carboxylic ester + H2O = an alcohol + a carboxylate. Most enzymes from this group belong to the superfamily of hydrolases with alpha/beta protein fold (so called Alpha/beta hydrolase fold), specifically those acting on carboxylic ester bonds. The carboxylesterase family of evolutionarily related proteins (those with clear sequence homology to each other) includes a number of proteins with different substrate specificities, such as acetylcholinesterases. Carboxylesterase 3, also known as Liver carboxylesterase 31 homolog and CES3, is a endoplasmic reticulum lumen which belongs to the type-B carboxylesterase/lipase family. CES3 is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. CES3 shows low catalytic efficiency for hydrolysis of CPT-11, a prodrug for camptothecin used in cancer therapeutics. CES3 is expressed in liver, colon and small intestine. 參考文獻
Augusteyn RC. et al.,1969, Biochim Biophys Acta. 171 (1): 128-37. Saito S. et al., 2003, J. Hum. Genet. 48: 249-70. Sanghani SP. et al., 2003, Clin Cancer Res. 9: 4983-91. Sanghani SP. et al., 2004, Drug Metab Dispos. 32: 505-11. Chen R. et al., 2009, J Proteome Res. 8: 651-61. 規格:10ug 關 鍵 詞:Mouse CES3 / Carboxylesterase-3 Protein,技術資料,廠家現貨,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家
CANSPEC品質提供的Mouse CES3 / Carboxylesterase-3 Protein|技術資料|廠家現貨性能**,其優良的品質滿足您不同實驗的多種需求。
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