Cynomolgus IFNB1 / IFN-beta / Interferon beta Protein|價格|廠家現貨

IFNB1 / IFN-beta / Interferon beta蛋白產品信息

別名: IFNB1
表達方式: 
A DNA sequence encoding the cynomolgus IFNB1(G7NFX1) (Met1-Asn187) was expressed with Fc region of mouse IgG at the C-terminus.
種屬: Cynomolgus
表達宿主: Human Cells

IFNB1 / IFN-beta / Interferon beta Protein QC Testing

純度: > 85 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Met 22
分子量: 
The recombinant cynomolgus IFNB1 is a disulfide-linked homodimer. The reduced monomer comprises 400 amino acids and has a calculated molecular mass of 46.4 KDa.The apparent molecular mass of the protein is approximately 44-49 KDa respectively in SDS-PAGE.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IFNB1 / IFN-beta / Interferon beta Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IFNB1 / IFN-beta / Interferon beta蛋白背景綜述

Interferon beta 1(IFN beta1) or IFNB1 is one type of IFN beta proteins that is a member of the Interferon type I family. Interferon beta 1(IFN beta1) or IFNB1 is produced in large quantities by fibroblasts and binds to a specific cell surface receptor complex known as the IFN alpha receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains as other members of IFN1 famlily do. The induction of interferon beta (IFNB1) is a key event in the antiviral immune response. It has shown that treatment with IFN beta affects NK cell cycle without altering NK cell apoptosis in MS patients. Treated with IFN beta alone or in combination with low-dose prednisolone displayed increased proportion of all NK cell subsets in the active phase of the cell cycle. There was no difference in NK cell apoptosis markers. Synthetic interferons (IFNs) are used in the treatment of several types of cancer. It has also been proved that apoptosis was decreased by IFN treatment, whereas inhibition of proliferation is caused by cell cycle arrest in late S-phase.

參考文獻

Sanvito L. et al., 2011, J Neuroimmunol. 236 (1-2): 111-7.
Erdmann J. et al., 2011, J Interferon Cytokine Res. 31 (5): 451-8.
Biron CA. et al., 2002, Curr Top Microbiol Immunol. 263: 7-27.

規格：50ug

關 鍵 詞：Cynomolgus IFNB1 / IFN-beta / Interferon beta Protein，價格，廠家現貨，實驗室耗材，生化試劑，上海創賽，博飛美科，實驗儀器，廠家

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