DBH / Dopamine beta-Hydroxylase Protein|技術資料|現貨

DBH / Dopamine beta-Hydroxylase蛋白產品信息

別名: DBH
表達方式: 
A DNA sequence encoding the human DBH (P09172) (Ser26-Gly603) was expressed with an N-terminal polyhistidine tag.
種屬: Human
表達宿主: Human Cells

DBH / Dopamine beta-Hydroxylase Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: His
分子量: 
The recombinant human DBH comprises 598 amino acids and has a predicted molecular mass of 67.3 kDa. The apparent molecular mass of the protein is approximately 68 kDa in SDS-PAGE under reducing conditions due to glycosylation.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

DBH / Dopamine beta-Hydroxylase Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

DBH / Dopamine beta-Hydroxylase蛋白背景綜述

DBH, also known as dopamine beta-Hydroxylase, is a 290 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH contains our identical subunits, and its activity requires ascorbate as a cofactor. It functions in in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only transmitter synthesized inside vesicles. DBH has been shown to be associated with decision making and addictive behaviors such as alcohol and smoking, attention deficit hyperactivity disorder, and also with neurological diseases such as Schizophrenia and Alzheimer's.

參考文獻

Rush RA. et al., 1980, Crit Rev Clin Lab Sci. 12 (3): 241-77.
Goldstein M. et al., 1964, Life Sci. 3 (7): 763-7.
S Friedman. et al., 1966, The Journal of Biological Chemistry. 241 (10): 2256-9.

規格：10ug

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