Canine CX3CL1 / Fractalkine / NTN Protein|使用說明|價格

CX3CL1 / Fractalkine / NTN蛋白產品信息

別名: CX3CL1
表達方式: 
A DNA sequence encoding the canine CX3CL1 (H1ADY9) (Met1-Arg379) was expressed with six amino acids (LEVLFQ) at the C- terminus.
種屬: Canine
表達宿主: Human Cells

CX3CL1 / Fractalkine / NTN Protein QC Testing

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Gln 25
分子量: 
The recombinant canine CX3CL1 is a disulfide-linked homodimer. The reduced monomer comprises 362 amino acids and has a predicted molecular mass of 38.2 kDa. The apparent molecular mass of the protein is approximately 64-69 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CX3CL1 / Fractalkine / NTN Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CX3CL1 / Fractalkine / NTN蛋白背景綜述

Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a large cytokine protein containing multiple domains and is the only known member of the CX3C chemokine family. It is also commonly known as fractalkine (in humans) and neurotactin (in mice). The polypeptide structure of CXC3L1/ NTN / Fractalkine differs from the typical structure of other chemokines. Mature human CX3CL1/ NTN / Fractalkine consists of a 76 aa residue chemokine domain, a 241 aa residue stalk region containing 17 degenerate mucin-like repeats, a 19 aa residue transmembrane segment and a 37 aa residue cytoplasmic domain. The extracellular domain of human CX3CL1/ NTN / Fractalkine can be released, possibly by proteolysis at the dibasic cleavage site proximal to the membrane, to generate soluble CX3CL1/ NTN / Fractalkine. Soluble CX3CL1/ NTN / Fractalkine potently chemoattracts T cells and monocytes, while the cell-bound CX3CL1/ NTN / Fractalkine promotes strong adhesion of leukocytes to activated endothelial cells where it is primarily expressed. CX3CL1/ NTN / Fractalkine elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1/ NTN / Fractalkine.

參考文獻

Bazan JF. et al.,1997, Nature. 385: 640-4.
Imai T. et al., 1997, Cell. 91: 521-30.
Nomiyama H. et al., 1998, Cytogenet Cell Genet. 81: 10-11.
Papadopoulos E. et al., 1999, Eur J Immunol. 29 (8): 2551-9.
Umehara H. et al., 2004, Arterioscler Thromb Vasc Biol. 24 (1): 34-40.

規格：20ug

關 鍵 詞：Canine CX3CL1 / Fractalkine / NTN Protein,使用說明,價格，實驗室耗材，生化試劑，上海創賽，博飛美科，實驗儀器，廠家

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