IL11RA / IL-11RA / IL11Rα蛋白產品信息
別名: IL11RA 表達方式: A DNA sequence encoding the canine IL11RA (XP_538710.4) (Met1-Leu363) was expressed with six amino acids (LEVLFQ) at the C- terminus. 種屬: Canine 表達宿主: Human Cells IL11RA / IL-11RA / IL11Rα Protein QC Testing
純度: > 90 % as determined by SDS-PAGE SDS-PAGE 內**: < 1.0 EU per μg of the protein as determined by the LAL method 穩定性: Samples are stable for up to twelve months from date of receipt at -70℃ 預測N端: Val 23 分子量: The recombinant canine IL11RA is a disulfide-linked homodimer. The reduced monomer comprises 348 amino acids and has a predicted molecular mass of 37.8 kDa. The apparent molecular mass of the protein is approximately 43-47 kDa in SDS-PAGE under reducing conditions. 緩沖液: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. IL11RA / IL-11RA / IL11Rα Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. IL11RA / IL-11RA / IL11Rα蛋白背景綜述
Interleukin-11 receptor alpha chain, also known as IL-11R-alpha, and IL11RA, is a single-pass type I membrane protein. It belongs to the type I cytokine receptor family and type 3 subfamily and contains two fibronectin type-III domains and one Ig-like C2-type (immunoglobulin-like) domain. Interleukin 11 receptor is a heterodimer composed of an interleukin 11 receptor alpha subunit and an incompletely characterized beta subunit. IL11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. IL11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and differentiation of skeletogenic progenitor or other mesenchymal cells. 參考文獻
Chérel M. et al., 1995, Blood. 86 (7): 2534-40. Chérel M. et al., 1996, Genomics. 32 (1): 49-53. Van Leuven F. et al., 1996, Genomics. 31 (1): 65-70. Li R. et al., 2001, Reproduction. 122 (4): 593-600. 規格:50ug 關 鍵 詞:Canine IL11RA / IL-11RA / IL11Rα Protein,技術資料,價格,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家
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