BAFFR / TNFRSF13C蛋白產品信息
別名: TNFRSF13C 表達方式: A DNA sequence encoding the rat TNFRSF13C (XP_576316.2) (Ser10-Ala71) was expressed with the Fc region of human IgG1 at the C-terminus. 種屬: Rat 表達宿主: Human Cells BAFFR / TNFRSF13C Protein QC Testing
純度: > 90 % as determined by SDS-PAGE SDS-PAGE 內**: < 1.0 EU per μg of the protein as determined by the LAL method 穩定性: Samples are stable for up to twelve months from date of receipt at -70℃ 預測N端: Ser 10 分子量: The recombinant rat TNFRSF13C/Fc is a disulfide-linked homodimer. The reduced monomer comprises 303 amino acids and has a predicted molecular mass of 33.8 kDa. The apparent molecular mass of the protein is approximately 42 kDa in SDS-PAGE under reducing conditions due to glycosylation. 緩沖液: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. BAFFR / TNFRSF13C Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. BAFFR / TNFRSF13C蛋白背景綜述
Tumor necrosis factor receptor superfamily member 13C, also known as B-cell-activating factor receptor, BAFF receptor, BLyS receptor 3, CD268, TNFRSF13C and BAFFR, is a single-pass type III membrane protein which contains one TNFR-Cys repeat. TNFRSF13C / BAFFR is highly expressed in spleen and lymph node, and in resting B-cells. It is detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. TNFRSF13C / BAFFR is a B-cell receptor specific for TNFSF13B / TALL1 / BAFF / BLyS. TNFRSF13C / BAFFR promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins. 參考文獻
Thompson JS. et al., 2001, Science. 293 (5537): 2108-11. Laabi Y. et al., 2002, Curr Biol. 11 (24): R1013-6. Defrance T. et al.,2003, Adv Cancer Res. 86: 195-225. Ambrose CM. et al., 2003, J Biol Regul Homeost.Agents. 16 (3): 211-3. 規格:50ug 關 鍵 詞:Rat BAFFR / TNFRSF13C Protein,鼠BAFFR / TNFRSF13C蛋白質,使用說明,價格,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家
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