ACVR2B / ACTRIIB蛋白產品信息
別名: ACVR2B 表達方式: A DNA sequence encoding the cynomolgus ACVR2B (EHH16502.1) (Ser28-Thr143) was expressed with the Fc region of human IgG1 at the C-terminus. 種屬: Cynomolgus 表達宿主: Human Cells ACVR2B / ACTRIIB Protein QC Testing
純度: > 90 % as determined by SDS-PAGE SDS-PAGE 內**: < 1.0 EU per μg of the protein as determined by the LAL method 穩定性: Samples are stable for up to twelve months from date of receipt at -70℃ 預測N端: Ser 28 分子量: The recombinant cynomolgus ACVR2B comprises 357 amino acids and has a calculated molecular mass of 40.3 KDa.The apparent molecular mass of the protein is approximately 54-62 KDa in SDS-PAGE. 緩沖液: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. ACVR2B / ACTRIIB Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. ACVR2B / ACTRIIB蛋白背景綜述
Activin A receptor, type I IB, also known as ACTRIIB, or ACVR2B, is an activin type 2 receptor. Activins are dimeric growth and differentiation factors belonging to the TGF-beta superfamily. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. On ligand binding, Type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently the initiates activation of downstream molecules. The activin A type IIB receptor displays a 3- to 4-fold higher affinity for the ligand than the type II receptor. Mouse activin receptor IIB (ACVR2B) is a transmembrane proteins consisting of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane segment, a cytoplasmic domain with predicted serine/threonine specificity, and as well as a C-terminal PDZ binding motif . Mouse ACVR2B shares 99% aa sequence identity with human and rat within ECD. 參考文獻
Hilden K. et al., 1994, Blood. 83: 2163-70. Persson U. et al., 1997, J Biol Chem. 272: 21187-94. Manova K. et al., 1995, Mech Dev. 49: 3-11. Matzuk MM. et al., 1992, Biochem Biophys Res Commun.185: 404-13. 規格:100ug 關 鍵 詞:Cynomolgus ACVR2B / ACTRIIB Protein,技術資料,價格,實驗室耗材,生化試劑,上海創賽,博飛美科,實驗儀器,廠家
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