Mouse GLIPR1 / RTVP1 Protein|使用說明|參數|價格

GLIPR1 / RTVP1蛋白產品信息

別名: GLIPR1
表達方式: 
A DNA sequence encoding the mouse GLIPR1 (NP_082884.1) (Met1-Thr223) was expressed with a C-terminal polyhistidine tag.
種屬: Mouse
表達宿主: Human Cells

GLIPR1 / RTVP1 Protein QC Testing

純度: > 85 % as determined by SDS-PAGE SDS-PAGE
內**: < 1.0 EU per μg of the protein as determined by the LAL method
穩定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Ser 18
分子量: 
The recombinant mouse GLIPR1 comprises 217 amino acids and has a predicted molecular mass of 25.1 kDa. The apparent molecular mass of the protein is approximately 28-32 kDa in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

GLIPR1 / RTVP1 Protein Usage Guide

儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

GLIPR1 / RTVP1蛋白背景綜述

Glioma pathogenesis-related protein 1, also known as Protein RTVP-1, GLIPR1 and GLIPR, is a single-pass membrane protein which belongs to the CRISP family. GLIPR1 / RTVP-1 was expressed in high levels in glioblastomas, whereas its expression in low-grade astrocytomas and normal brains was very low. Transfection of glioma cells with small interfering RNAs targeting GLIPR1 / RTVP-1 decreased cell proliferation in all the cell lines examined and induced cell apoptosis in some of them. Overexpression of GLIPR1 / RTVP-1 increased astrocyte and glioma cell proliferation and the anchorage-independent growth of the cells. In addition, overexpression of GLIPR1 / RTVP-1 rendered glioma cells more resistant to the apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand and serum deprivation. GLIPR1 / RTVP-1 regulated the invasion of glioma cells was evident by their enhanced migration through Matrigel and by their increased invasion in a spheroid confrontation assay. The increased invasive potential of the GLIPR1 / RTVP-1 overexpressors was also shown by the increased activity of matrix metalloproteinase 2 in these cells. The expression of GLIPR1 / RTVP-1 is correlated with the degree of malignancy of astrocytic tumors and that GLIPR1 / RTVP-1 is involved in the regulation of the growth, survival, and invasion of glioma cells. GLIPR1 / RTVP-1 is a potential therapeutic target in gliomas.

參考文獻

Murphy EV. et al., 1995, Gene. 159: 131-5.
Rich T. et al., 1996, Gene. 180: 125-30.
Rosenzweig T. et al., 2006, Cancer Res. 66 (8): 4139-48.

規格：10ug

關 鍵 詞：Mouse GLIPR1 / RTVP1 Protein,使用說明,參數,價格，實驗室耗材，生化試劑，上海創賽，博飛美科，實驗儀器，廠家

CANSPEC品質提供的Mouse GLIPR1 / RTVP1 Protein|使用說明|參數|價格性能**，其優良的品質滿足您不同實驗的多種需求。

本產品由上海創賽品質提供，歡迎咨詢國內免費服務專線：400-608-7598，更多產品信息請登錄www.getprovidencehotels.com 或 www.4006087598.com